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1 tablet coated with Generic Cialis contains: Tadalafil - 20 mg;

Additional ingredients, including lactose.

Pharmacological group


Means used to treat sexual dysfunction in men

 

Pharmacologic effect of Generic Cialis


Generic Cialis is a drug containing tadalafil. The active component of the drug reversibly selectively inhibits cyclic guanosine monophosphate (cGMP) - a specific type 5 phosphodiesterase (PDE 5). During sexual stimulation, a local release of nitric oxide is noted, while inhibition of the activity of specific type 5 phosphodiesterase leads to an increase in the level of cyclic guanosine monophosphate in the cavernous body. Under the influence of tadalafil there is a decrease in the tone of smooth muscles and an increase in blood flow to the tissues of the penis, which contributes to an improvement in erection. Tadalafil does not have sexual stimulation.

 

The efficacy and safety of Cialis ® (at doses of 2.5 mg and 5 mg) was studied in clinical trials. There was an improvement in erection in patients with erectile dysfunction of all severity levels when taking tadalafil 1 time/day. In studies on the primary efficacy of tadalafil at a dose of 5 mg, 62% and 69% of attempts at intercourse were successful compared with 34% and 39% of patients taking a placebo. Tadalafil in a dose of 5 mg significantly improved the erectile function within 24 hours between doses.

 

The effect of tadalafil on other phosphodiesterases is insignificant, so Cialis has no effect on the cardiovascular system, liver function, skeletal muscles and other organs. Tadalafil does not change the qualitative characteristics of sperm, does not cause a change in the level of testosterone, follicle-stimulating and luteinizing hormone in the blood. Generic Cialis for sale - Buy Cialis from the trusted online store only.

 

The effect of the drug Cialis develops only under the condition of sexual stimulation. The beginning of the therapeutic effect of tadalafil occurs 15 minutes after admission. Cialis is effective for 36 hours after oral administration.

 

The active ingredient of Cialis is well absorbed after oral administration. The peak of plasma concentration of tadalafil is reached within 2 hours after administration. 

Bioavailability and absorption rate of tadalafil does not depend on food intake. About 94% of tadalafil binds to plasma proteins. The active component of the preparation Cialis is metabolized with the participation of the enzyme CYP3 A4. Excreted tadalafil mainly in the form of metabolites of the intestine and kidneys, the half-life reaches 17.5 hours. Buy Cheap Generic Cialis Online, US Online Store for Generic Cialis. Fast delivery by airmail, we sale brand and generic pills throughout the United States!

 

Indications for use


Cialis is used to treat patients with erectile dysfunction.

 

Mode of application


Cialis is intended for oral administration. Tablets, coated with a shell, it is recommended to take whole, squeezed with enough drinking water or tea. Cialis is taken regardless of food intake. The procedure for taking Cialis is determined by the doctor. 

Usually prescribe the reception of 1 tablet, covered with a shell, 15-20 minutes before the expected sexual activity. Given that the effect after a single dose is stored up to 36 hours, the pill can be taken earlier.

 

The maximum recommended a daily dose of Cialis is 1 tablet.

 

Side effects


When taking Cialis, patients may develop a headache and dyspepsia. In addition, there have been reports of single cases of back pain, hyperemia of the face, nasal obstruction, myalgia, eye pain, conjunctival hyperemia, dizziness and edema of Quincke during admission of tadalafil.

 

There is evidence of the development of priapism and prolonged erections with the administration of Cialis. If the erection persists for more than 4 hours, you should seek medical help, as long-term preservation of the erection can cause damage to the tissues of the penis and a long-term loss of potency.

 

Contraindications


Cialis is not prescribed to patients with known hypersensitivity to tadalafil.

The administration of Cialis is contraindicated in patients receiving organic nitrates.

Tadalafil is not prescribed for women and children under 18 years of age.

It is not recommended to take Cialis medication for patients with cardiovascular diseases, in which sexual activity is undesirable, including patients who have recently had myocardial infarction or apoplexy, as well as those with second-degree heart failure, unstable angina, uncontrolled arrhythmia or hypertension, hypotension.

 

Caution should be given to administering Cialis to patients at increased risk of priapism, including patients with leukemia, sickle-cell anemia, myeloma, an angular curvature of the penis, cavernous fibrosis and Peyronie's disease.

 

In addition, caution should be observed by appointing tadalafil to patients suffering from impaired renal and hepatic function and to patients receiving alpha-blockers.

 

Cialis Generic Cost


The cost of generic Cialis depends on the quantity you buy. If you buy Cialis online in bulk then it would be cheaper to you.

 

Drug Interactions

-       The simultaneous use of organic nitrates with tadalafil is prohibited.

-       Tadalafil does not change the pharmacokinetic profile of drugs metabolized with the participation of the cytochrome P450 system.

 

With the combined administration of Cialis and CYP3 A4 inhibitors, an increase in plasma concentrations of tadalafil is possible. In particular, caution should be used with tadalafil combined with ketoconazole, ritonavir, saquinavir, erythromycin, and itraconazole.

 

It is possible to reduce plasma concentrations of tadalafil when combined with CYP3 A4 inducers, in particular, rifampicin.

 

Cialis, when combined, can potentiate the effect of antihypertensive agents.

Antatsidnye and enveloping agents reduce the bio availability of tadalafil at the combined reception.

 

Overdose


When taking excessive doses of Cialis, patients developed unwanted reactions similar to those of tadalafil with therapeutic doses.  There is no specific antidote. When developing signs of an overdose, symptomatic therapy is performed. Conducting hemodialysis does not lead to a significant decrease in plasma concentrations of tadalafil.

 

Form of issue


Tablets coated with Cialis in blister packs of 1, 2, 4 or 8 pieces, in a cardboard bundle 1 blister pack.

 

Storage conditions


Cialis from online pharmacy store should be stored no more than 2 years after manufacturing in rooms with a temperature regime of 15 to 30 degrees Celsius.

 

Where can I Buy Generic Cialis online?


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