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kamagra Web Blog
July 25, 2018

kamagra Web Blog

Kamagra 100 MG or Sildenafil is prescribed for the treatment of persistent erectile dysfunction in men. Erectile dysfunction can be defined as inability to achieve and to maintain normal penis erection in the presence of sexual stimulation. Approximately 30 million men in the US suffer from varying degrees of erectile dysfunction. Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

Physiologically rigidity of erection depends on the balance between the production and destruction of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which are continuously being destroyed by phosphodiesterase (PDE) enzymes. PDE- 5 inhibitors like sildenafil inhibit this cycle of destruction and make penile and vascular smooth muscle cells to dilate.

How does Kamagra 100 work?

Normally in presence of sexual stimulation a potent vasodilator i.e., nitric oxide releases from the corpus cavernosum (pair of sponge-like regions of erectile tissue). Release of nitric acid triggers the activity of enzyme guanylate cyclase which subsequently increases the level of cyclic-guanosine monophosphate (cGMP). Increase in the concentration of cGMP leads to enhance dilation of epithelial smooth muscles of corpus cavernosum. Dilation of corpus cavernosum allows more blood influx into penis thus making it rigid and erect.

Kamagra 100 being a cGMP specific PDE5 inhibitor promotes the activity of local nitric oxide by specifically inhibiting PDE5 enzyme (responsible for biodegradation of cGMP) in corpus cavernosum. Increase level of nitric acid and subsequently cGMP result in smooth muscle dilatation and increased influx of blood to the corpus cavernosum.
Kindly note: Kamagra 100 will only exhibit its effect in presence of sexual stimuli.

What are the active ingredients of Kamagra 100?

Each film coated tablet of Kamagra 100 consists of:
Sildenafil 100 mg
Excipients QS
Coloring agents

Contraindications associated with Kamagra 100
  • It is contraindicated in patients with known history of hypersensitivity to Sildenafil or any of the other ingredients present in Kamagra 100
  • Since sildenafil have prominent effect nitric oxide so it potentiates vasodilatory effect of nitrates and nitrate like drugs. Co-administration of sildenafil and nitrate can result in amplified hypotension effect. So in patients who are on nitrate drug therapy (in any form either regular or intermittently) use of sildenafil is highly contraindicated.
  • In patients with severe hepatic and renal dysfunctioning (CLcr <30 mL/min) use of Kamagra 100 is contraindicated
  • Use of Kamagra 100 is absolutely contraindicated in patient with recent history (past 6 months) of ischemic heart disease, myocardial infarction, in patients with permanent pacemaker, arrhythmia, heart stroke or optic neuropathy.
What are the warnings/precautions related to Kamagra 100?
  • It is recommended to consult physician prior to administration of Kamagra 100.
  • Kamagra 100 is not recommended in individuals < 18 years and in women
  • Potent CYP3A4 inhibitors like ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone can potentially increase the plasma concentration of sildenafil. Sildenafil dosage needs to modify when co-administered with CYP3A4.
  • Significant alcohol consumption with this medication can cause symptoms of orthostatic hypotension and syncope like light-headedness, weakness, blurred vision. 
  • Sexual activity is associated with potential cardiac risk therefore in patients with history of cardiovascular disorders prescription of medicine use for treatment of erectile dysfunction should be limited.
  • Caution is advice in concomitant use of alpha blockers and Kamagra 100 may result in additive effect on blood pressure. It may lead to symptomatic hypotension.
  • Concurrent use of Kamagra 100 may potentiate vasodilatory effect of anti-hypertensive drugs leading to additional drop in blood pressure. 
  • Patient is advised to immediately discontinue and seek medical assistance in case of loss of vision. Sudden loss of vision can be a sign of non-arteritic anterior ischaemic optic neuropathy.
  • Patients with penis deformation or suffering from conditions like sickle cell anaemia, multiple myeloma can experience prolonged and painful erection.
  • Caution is advised while using Sildenafil in patients with bleeding disorders like peptic ulcer
  • Risk benefit ration should be assessed while using Sildenafil in patients with untreated diabetic retinopathy
  • The safety and efficacy of Kamagra 100 with other PDE-5 inhibitors have not been studied in detail. So caution is advised while using this medication with other PDE-5 inhibitors.
What are the expected side-effects?
  • Painful and prolonged erection
  • Headache
  • Dizziness
  • Flushing
  • Back and limbic pain
  • Nasal congestion, rhinitis
  • Visual deformity or blurred vision
  • Sudden decrease in hearing ability, ringing sound 
  • Rashes 
  • Abdominal discomfort
  • Nausea and vomiting
  • Diarrhea

Listed above are not all the side-effects related to Sildenafil. For further information on side-effects please go through the product insert. Consult your physician immediately if any of the above side effects is experienced while using this medication.

What are the possible drug interactions?
  • In presence of potent CYP3A4 inhibitors and CYP3A4 inducer the rate of clearance of sildenafil reduces and increases respectively.
  • Concurrent use of Kamagra 100 with nitrates like isosorbide and monosorbide nitrate, nitroglycerine is contraindicated
  • Use of Kamagra with alpha-blockers is recommended with caution
  • Caution is advised with co-administration of other PDE-5 inhibitors and antihypertensive drug like amlodipine
  • Alcohol
What should be done if dose is missed?

If you missed a dose of Kamagra 100 dose, and you remember it the same day take it as soon as you remember. But if you don’t remember until the next day, then never try to compensate a missed dose. Skip a missed dose and take the drug as it was schedule by your doctor.

What should be done in case of overdosing?

Symptoms of Kamagra 100 overdosing can be life-threatening. Symptoms can vary from moderate to severe gastrointestinal irritation to high BP, tremor, dizziness. In case of overdosing immediately contact doctor.

What is the dosage regimen, and how medicine should be taken?
  • Kamagra 100 is intended for only oral use.
  • This medicine is recommended once daily about 30 minutes before initiation of sexual activity. But it can also be administered 1 to 4 hours prior to sexual intercourse. 
  • It should we swallowed with water.
  • It can be taken with or without food.
  • Dose adjustment by physician is required in specific patients’ population.
What are the storage instructions?
  • Sildenafil should be stored in cool and dry place, below 20o C temperature.
  • Do not expose the medication to extreme heat or freezing temperature.
  • Keep out of the reach of children and pets.
  • The medicine should be checked properly for the expiry date before applying it.
  • Properly discard the expired medication. 
  • Do not flush the medicine if not instructed to do so.